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ADC Linkers

Mal-Amide-PEG4-Glu-Gly-Cit-PAB-MMAE

Catalog: TASK-21-2000013   CAS NO.: N/A
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Description

Mal-Amide-PEG4-Glu-Gly-Cit-PAB-MMAE is a complex molecule designed for use in the development of antibody-drug conjugates (ADCs). Maleimide is a functional group that is commonly used in bioconjugation reactions. It reacts selectively with thiol groups to form stable thioether linkages. The amide bond is a functional group that forms a linkage between the mal group and the PEG linker. Amide bonds are stable under physiological conditions. PAB is a linker component that can serve as a spacer between the PEG linker and the cytotoxic payload. It contributes to flexibility and prevents steric hindrance. MMAE is a potent cytotoxic agent derived from the natural product dolastatin 10. It inhibits cell division by disrupting microtubule dynamics and is commonly used as a payload in ADCs.

Specifications

CAS No.N/A
FormulaC78H121N13O23
Molecular Weight1607.9
Purity98%
Ship Within1 week
Storage Temp.-20℃
Shipping4-25℃ for up to 3 weeks
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