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ADC Linkers

Mal-Amido-PEG2-Val-Cit-PAB-PNP

Catalog: TASK-21-1000039   CAS NO.: 2112738-13-1
  • 1g

$68.25$68.25

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Description

Mal-Amido-PEG2-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADC). Maleimide groups are known for reacting specifically with thiol (-SH) groups, such as those present in cysteine residues of proteins. Amide bonds are commonly used for linking different molecules together, and they are found in various bioconjugation strategies. The Val-Cit is specifically cleaved by cathepsin B. PAB is often used as a linker in drug conjugates to attach other molecules, such as cytotoxic drugs or imaging agents, to a targeting ligand. PNP is a good leaving group when reacting with amine containing molecule.

Specifications

CAS No.2112738-13-1
FormulaC39H50N8O14
Molecular Weight854.9
Purity98%
Ship Within1 week
Storage Temp.-20℃
Shipping4-25℃ for up to 3 weeks
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