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APIs & Intermediates

4-Dehydroxy-4-amino Ezetimibe | CAS 1354716-98-5

Catalog: TASK-37-1000751   CAS NO.: 1354716-98-5
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Description

4-Dehydroxy-4-amino Ezetimibe ((3R,4S)-4-(4-Aminophenyl)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-2-azetidinone / (3R,4S)-4-(4-Aminophenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)azetidin-2-one) is a derivative of Ezetimibe, a selective inhibitor of the Niemann-Pick C1-like 1 (NPC1L1) protein, which plays a crucial role in cholesterol absorption. The presence of an amino group at the 4-position could affect the compound’s interaction with the NPC1L1 protein and its overall pharmacological profile. Ezetimibe works by inhibiting the NPC1L1 protein, which reduces the absorption of cholesterol in the intestines. The impact of removing the hydroxyl group and adding the amino group on this activity should be evaluated. The compound’s potential applications span drug development, cholesterol management, pharmacokinetics, and medicinal chemistry. This product is available in kilograms. Please kindly contact us if you are in request.

Specifications

CAS No.1354716-98-5
FormulaC24H22F2N2O2
Molecular Weight408.44
Purity>98%
Ship Within1 week
Storage Temp.N/A
Shipping4-25℃ for up to 3 weeks
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