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ADC Linkers

Val-Cit-PAB-MMAF

Catalog: TASK-21-1000080   CAS NO.: 863971-56-6
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$68.25$68.25

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Description

Val-Cit-PAB-MMAF is a cleavable ADC linker bound to Monomethyl auristatin F (MMAF). MMAF is an antitubulin agent that inhibits cell division by blocking the polymerization of tubulin. PAB is a typical self-immolation spacer. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell.

Specifications

CAS No.863971-56-6
FormulaC58H92N10O13
Molecular Weight1137.4
Purity98%
Ship Within1 week
Storage Temp.-20℃
Shipping4-25℃ for up to 3 weeks
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