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ADC Linkers

MC-Val-Cit-PAB-MMAF

Catalog: TASK-21-1000081   CAS NO.: 863971-17-9
  • 5mg
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  • 25mg

$68.25$68.25

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Description

MC-Val-Cit-PAB-MMAF is a agent-linker conjugate for ADC by using the tubulin inhibitor, MMAF, linked via cathepsin cleavable MC-Val-Cit-PAB. It shows antitumor activity. MMAF is a cytotoxic agent that is used in antibody-drug conjugates (ADCs) for targeted cancer therapy. MMAF can selectively kill cancer cells when delivered specifically to those cells. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. PAB is a typical self-immolation spacer.

Specifications

CAS No.863971-17-9
FormulaC68H103N11O16
Molecular Weight1330.6
Purity98%
Ship Within1 week
Storage Temp.-20℃
Shipping4-25℃ for up to 3 weeks
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