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ADC Linkers

Azido-PEG8-Amido-Val-Cit-PAB-PNP

Catalog: TASK-21-1000051   CAS NO.: N/A
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  • 250mg

$68.25$68.25

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Description

Azido-PEG8-Amido-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADC). Azide is commonly used in bioconjugation reactions, particularly in “click chemistry,” where they can react selectively with alkyne or other suitable groups. Amide bonds are commonly used for linking different molecules together, and they are found in various bioconjugation strategies. The Val-Cit is specifically cleaved by cathepsin B. PAB is often used as a linker in drug conjugates to attach other molecules, such as cytotoxic drugs or imaging agents, to a targeting ligand. PNP is a good leaving group when reacting with amine containing molecule.

Specifications

CAS No.N/A
FormulaC47H72N10O19
Molecular Weight1081.2
Purity98%
Ship Within1 week
Storage Temp.-20℃
Shipping4-25℃ for up to 3 weeks
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