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ADC Linkers

NHS ester-PEG4-Val-Cit-PAB-MMAE

Catalog: TASK-21-1000068   CAS NO.: 2762518-86-3
  • 10mg
  • 20mg

$68.25$68.25

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Description

NHS ester-PEG4-Val-Cit-PAB-MMAE is a precursor of antibody drug conjugate. It contains a PEG4 spacer, a protease-sensitive Val-Cit dipeptide, a PAB linker and an MMAE payload. It can be attached to a monoclonal antibody (MAB) which directs it toward cancer cells. The MMAE is a synthetic antineoplastic agent. It acts as a potent mitotic inhibitor by inhibiting tubulin polymerization. Valine-citrulline is a common lysosomal cleavable dipeptide. PAB is a typical self-immolation spacer.

Specifications

CAS No.2762518-86-3
FormulaC74H117N11O21
Molecular Weight1496.8
Purity98%
Ship Within1 week
Storage Temp.-20℃
Shipping4-25℃ for up to 3 weeks
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