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Polymers & Copolymers

PEGylated Polyamidoamine (PAMAM) Dendrimer Conjugates with Bis-aryl Hydrazone (BAH) Linkages

Catalog: TASK-8-4000161   CAS NO.: N/A
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Description

PEGylated Polyamidoamine (PAMAM) Dendrimer Conjugates with Bis-aryl Hydrazone (BAH) Linkages are specialized nanostructures that combine the biocompatibility of PEG (polyethylene glycol) with the high loading capacity and precise architecture of PAMAM dendrimers, linked via bis-aryl hydrazone (BAH) bonds. BAH bonds are acid-labile and form stable yet pH-sensitive linkages, ideal for controlled release in slightly acidic environments (such as tumor sites or intracellular compartments). PEGylated PAMAM dendrimers with BAH linkages enable targeted drug delivery, particularly to tumors or acidic cellular compartments. The dendrimer can carry multiple drug molecules, enhancing the therapeutic payload per carrier. The acid-sensitive release also allows for selective drug release within the target site, improving therapeutic efficacy while reducing systemic side effects. PAMAM dendrimers are commonly utilized in pharmaceuticals for targeted drug delivery and gene therapy, in diagnostics as biosensors and imaging agents, in cosmetics for active ingredient delivery, and in materials science for enhancing properties in nanocomposites and catalysts. Taskcm can provide PAMAM dendrimers in kilograms.

Specifications

CAS No.N/A
FormulaN/A
Molecular WeightN/A
Purity98%
Ship Within1-3 weeks
Storage Temp.N/A
Shipping4-25℃ for up to 3 weeks
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