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ADC Linkers

t-butyl ester-PEG4-Val-Cit-PAB-MMAE

Catalog: TASK-21-1000065   CAS NO.: N/A
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$68.25$68.25

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Description

t-butyl ester-PEG4-Val-Cit-PAB-MMAE can be used antibody drug conjugation as a precursor. It contains a PEG4 spacer, a protease-sensitive Val-Cit dipeptide, a PAB linker and an MMAE payload. It can be attached to a monoclonal antibody (MAB) which directs it toward cancer cells. The MMAE is a synthetic antineoplastic agent. It acts as a potent mitotic inhibitor by inhibiting tubulin polymerization. Valine-citrulline is a common lysosomal cleavable dipeptide. PAB is a typical self-immolation spacer.

Specifications

CAS No.N/A
FormulaC74H122N10O19
Molecular Weight1455.9
Purity98%
Ship Within1 week
Storage Temp.-20℃
Shipping4-25℃ for up to 3 weeks
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